Psychiatry Investig.  2008 Sep;5(3):142-147.

Triple Reuptake Inhibitors: A Premise and Promise

Affiliations
  • 1Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA. pae@catholic.ac.kr
  • 2Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.

Abstract

On the horizon there is a new class of psychoactive medications which work by inhibiting the neuronal reuptake of serotonin, norepinephrine, and dopamine. There are multiple potential indications for these drugs. Research suggests that they may have a role in treating depressive disorders, and it is plausible they may have potential efficacy in obesity, addiction, and pain syndromes. The current review describes some of the molecules in development presently and explores the research relevant to possible clinical uses for this class of medications.

Keyword

Triple reuptake inhibitor; Serotonin; Norephinephrine; Dopamine

MeSH Terms

Depressive Disorder
Dopamine
Neurons
Norepinephrine
Obesity
Serotonin
Dopamine
Norepinephrine
Serotonin
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