Korean J Urol.  2011 Apr;52(4):247-252.

Relationship between the Glutathione-S-Transferase P1, M1, and T1 Genotypes and Prostate Cancer Risk in Korean Subjects

• Kwon DD
• Lee JW
• Han DY
• Seo IY
• Park SC
• Jeong HJ
• Yang YS
• Chae SC
• Na KS
• Mo KJ
• Kim JJ
• Rim JS

Abstract

PURPOSE
The glutathione-S-transferase (GST)P1, GSTM1, and GSTT1 genotypes have been associated with an increased risk of prostate, bladder, and lung cancers. The aim of this study was to investigate the association between the GSTP1, GSTM1, and GSTT1 genotypes and the risk of prostate cancer in Korean men.
MATERIALS AND METHODS
The study group consisted of 166 patients with histologically confirmed prostate cancer. The control group consisted of 327 healthy, cancer-free individuals. The diagnosis of prostate cancer was made by transrectal ultrasound-guided biopsy. Patients with prostatic adenocarcinoma were divided into organ-confined (< or =pT2) and non-organ-confined (> or =pT3) subgroups. The histological grades were subdivided according to the Gleason score. The GSTP1, GSTM1, and GSTT1 genotypes were determined by using polymerase chain reaction-based methods. The relationship among GSTP1, GSTM1, and GSTT1 polymorphisms and prostate cancer in a case-control study was investigated.
RESULTS
The frequency of the GSTM1 null genotype in the prostate cancer group (54.2%) was higher than in the control group (odds ratio=1.53, 95% confidence interval=1.20-1.96). The comparison of the GSTP1, GSTM1, and GSTT1 genotypes and cancer prognostic factors, such as staging and grading, showed no statistical significance.
CONCLUSIONS
An increased risk for prostate cancer may be associated with the GSTM1 null genotype in Korean men, but no association was found with the GSTT1 or GSTP1 genotypes.

Keyword

Glutathione S-transferase M1; Glutathione S-transferase P1; Glutathione S-transferase T1; Prostatic neoplasms

MeSH Terms

Adenocarcinoma
Biopsy
Case-Control Studies
Genotype
Glutathione Transferase
Humans
Lung Neoplasms
Male
Neoplasm Grading
Prostate
Prostatic Neoplasms
Urinary Bladder
Glutathione Transferase

Figure

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  FIG. 1 Methods and results - glutathione-S-transferaseM1. PCR: polymerase chain reaction.

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  FIG. 2 Methods and result - glutathione-S-transferaseT1. PCR: polymerase chain reaction.

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