Twist and Shout: A Clinical and Experimental Review of Testicular Torsion

Ellati, Riyad T; Kavoussi, Parviz K; Turner, Terry T; Lysiak, Jeffrey J

Abstract

PURPOSE
This review addresses different aspects of testicular torsion from the clinical perspective as well as the basic cellular and molecular events responsible for the post-torsion testicular changes and pathology, including tissue ischemia-reperfusion injury.
MATERIALS AND METHODS
A review of all published literature on testicular torsion was performed by use of two search engines.
RESULTS
Testicular torsion, or more correctly termed torsion of the spermatic cord, is a surgical emergency in order to salvage the testis. Its incidence is approximately 1 in 4,000 per annum. Testicular torsion must be treated promptly to avoid loss of the ipsilateral testis; however, even with torsion repair and gross testicular salvage, significant injury may still occur.
CONCLUSIONS
The cellular and molecular mechanisms leading to ischemia-reperfusion injury are incompletely understood, and adjuncts to surgical treatment have received little attention. Understanding the cellular and molecular effects is important because 25% of males with a history of torsion may experience adult infertility. This review emphasizes current knowledge of basic science results and clinical outcomes of testicular torsion.