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Thrombolysis Improves Reperfusion and the Clinical Outcome in Tandem Occlusion Stroke Related to Cervical Dissection: TITAN and ETIS Pooled Analysis

Marnat G, Sibon I, Bourcier R, Anadani M, Gariel F, Labreuche J, Kyheng M, Mazighi M, Dargazanli C, Piotin M, Consoli A, Blanc R, Anxionnat R, Audibert G, Richard S, Lapergue B, Gory B, on Behalf of ETIS and TITAN Investigators

Background and Purpose Despite the widespread adoption of mechanical thrombectomy (MT) for the treatment of large vessel occlusion stroke (LVOS) in the anterior circulation, the optimal strategy for the treatment...
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Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

Yang L, Chen X, Bi Z, Liao J, Zhao W, Huang W

Apoptosis is proved responsible for renal damage during ischemia/reperfusion. The regulation for renal apoptosis induced by ischemia/reperfusion injury (IRI) has still been unclearly characterized to date. In the present study,...
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Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Yücel C, Gürsoy M, Ketenciler S, Tenekeciğil A, Kızıltan F, Kayalar N

Purpose: The hypoxia inducible factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body’s response to hypoxia. This study aimed to analyze the regulation of...
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Risk Factors and Clinical Outcomes of Brain Reperfusion Injury after Mechanical Thrombectomy for Ischemic Stroke

Moon JH, Choi HR

Purpose: The aim of this study was to investigate the risk factors for brain reperfusion injury in ischemic stroke patients and to analyze the clinical outcomes. Methods: A retrospective study...
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Factors Contributing to an Efficacious Endovascular Treatment for Acute Ischemic Stroke in Asian Population

Lee JS, Hwang YH, Sohn SI

Although randomized control trials about endovascular treatment (EVT) of emergent large vessel occlusion (LVO) have demonstrated the success of mechanical thrombectomy as the choice of treatment, a wide range of...
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Prediction of Early Recanalization after Intravenous Thrombolysis in Patients with Large-Vessel Occlusion

Kim YD, Nam HS, Yoo J, Park H, Sohn SI, Hong JH, Kim BM, Kim DJ, Bang OY, Seo WK, Chung JW, Lee KY, Jung YH, Lee HS, Ahn SH, Shin DH, Choi HY, Cho HJ, Baek JH, Kim GS, Seo KD, Kim SH, Song TJ, Kim J, Han SW, Park JH, Lee SI, Heo J, Choi JK, Heo JH, on behalf of the Thrombus Imaging Study Group and the SECRET Study Group

Background and Purpose We aimed to develop a model predicting early recanalization after intravenous tissue plasminogen activator (t-PA) treatment in large-vessel occlusion. Methods Using data from two different multicenter prospective cohorts,...
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Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1α/Nrf2 signaling pathway

Wang H, Shi X, Cheng L, Han J, Mu J

The present study explored the therapeutic potential of hydrogen sulfide (H2 S) in restoring aging-induced loss of cardioprotective effect of remote ischemic preconditioning (RIPC) along with the involvement of signaling...
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2021 Korean Society of Myocardial Infarction Expert Consensus Document on Revascularization for Acute Myocardial Infarction

Chang K, Ahn Y, Lim S, Yang JH, Lee KY, Choo EH, Kim HK, Nam CW, Kim W, Hwang JY, Rha SW, Kim HS, Cho MC, Jang Y, Jeong MH, tTFoECDotKSoMI(

Acute myocardial infarction (AMI) is a fatal manifestation of ischemic heart disease and remains a major public health concern worldwide despite advances in its diagnosis and management. The characteristics of...
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Radiomics of Non-Contrast-Enhanced T1 Mapping: Diagnostic and Predictive Performance for Myocardial Injury in Acute ST-Segment-Elevation Myocardial Infarction

Ma Q, Ma Y, Yu T, Sun Z, Hou Y

Objective: To evaluate the feasibility of texture analysis on non-contrast-enhanced T1 maps of cardiac magnetic resonance (CMR) imaging for the diagnosis of myocardial injury in acute myocardial infarction (MI). Materials and...
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Effect of Transport Time on the Use of Reperfusion Therapy for Patients with Acute Ischemic Stroke in Korea

Choi JC, Kim JG, Kang CH, Bae HJ, Kang J, Lee SJ, Park JM, Park TH, Cho YJ, Lee KB, Lee J, Kim DE, Cha JK, Kim JT, Lee BC, Lee JS, Kim AS

Background: We investigated the association between geographic proximity to hospitals and the administration rate of reperfusion therapy for acute ischemic stroke. Methods: We identified patients with acute ischemic stroke who visited...
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Role of Ischemic Preconditioning in the Cardioprotective Mechanisms of Monomeric C-Reactive Protein-Deposited Myocardium in a Rat Model

Kim EN, Choi JS, Kim CJ, Kim SR, Oh SJ

Background: The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. Methods: We...
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Which one to do first?: a case report of simultaneous acute ischemic stroke and myocardial infarction

Lee K, Park W, Seo KD, Kim H

Background: Although there are common risk factors for acute ischemic stroke and myocardial infarction, simultaneous onset of both diseases is uncommon. Here, we present a case of acute cerebral infarction...
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Metformin and Sildenafil Attenuate Inflammation and Suppress Apoptosis After Ischemia/Reperfusion Injuries in Rat Urinary Bladder

Park JM, Shin JH, Yang SW, Lee JY, Lee CL, Lim JS, Song KH, Kim GH, Na YG

Purpose: Although metformin and sildenafil can protect various organs against ischemia/reperfusion (I/R) injuries, their effects and mechanisms of action in bladder I/R injuries remain unknown. This study investigated the effects...
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Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Michino T, Tanabe K, Takenaka M, Akamatsu S, Uchida M, Iida M, Iida H

Background: Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment....
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General Anesthesia versus Conscious Sedation in Mechanical Thrombectomy

Feil K, Herzberg M, Dorn F, Tiedt S, Küpper C, Thunstedt DC, Hinske LC, Mühlbauer K, Goss S, Liebig T, Dieterich M, Bayer A, Kellert L, on Behalf of the GSR Investigators

Background and Purpose Anesthesia regimen in patients undergoing mechanical thrombectomy (MT) is still an unresolved issue. Methods We compared the effect of anesthesia regimen using data from the German Stroke Registry-Endovascular...
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Care Process of Recanalization Therapy for Acute Stroke during the COVID-19 Outbreak in South Korea

Kim YD, Nam HS, Sohn SI, Park H, Hong JH, Kim GS, Seo KD, Yoo J, Baek JH, Seo JH, Heo J, Baik M, Lee HS, Heo JH, on behalf of the SMART-EST Study Group

Background and Purpose We aimed to determine whether the care process and outcomes in patients with acute stroke who received recanalization therapy changed during the outbreak of coronavirus disease 2019...
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Effectiveness and Technical Considerations of Solitaire Platinum 4×40 mm Stent Retriever in Mechanical Thrombectomy with Solumbra Technique

Yi HJ, Sung JH, Lee DH, Song SY

Objective : The Solitaire Platinum 4×40 mm stent retriever contains radiopaque markers with a long length. We evaluated the effect of Solitaire Platinum 4×40 mm stent retriever in Solumbra technique...
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Human Recombinant Apyrase Therapy Protects Against Myocardial Ischemia/Reperfusion Injury and Preserves Left Ventricular Systolic Function in Rats, as Evaluated by 7T Cardiovascular Magnetic Resonance Imaging

Xu Z, Chen W, Zhang R, Wang L, Chen R, Zheng J, Gao F

Objective: The occurrence of intramyocardial hemorrhage (IMH) and microvascular obstruction (MVO) in myocardial infarction (MI), known as severe ischemia/reperfusion injury (IRI), has been associated with adverse remodeling. APT102, a soluble...
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Unfavorable Vascular Anatomy during Endovascular Treatment of Stroke: Challenges and Bailout Strategies

Alverne FJAM, Lima FO, Rocha FdA, Bandeira DdA, Lucena AFd, Silva HC, Lee JS, Nogueira RG

The benefit of mechanical thrombectomy (MT) in acute ischemic stroke (AIS) due to large vessel intracranial occlusions is directly related to the technical success of the procedures in achieving fast...
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2019 Update of the Korean Clinical Practice Guidelines of Stroke for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke

Ko SB, Park HK, Kim BM, Heo JH, Rha JH, Kwon SU, Kim JS, Lee BC, Suh SH, Jung C, Jeong HW, Kang DH, Bae HJ, Yoon BW, Hong KS

Endovascular recanalization therapy (ERT) has been a standard of care for patients with acute ischemic stroke due to large artery occlusion (LAO) within 6 hours after onset since the five...
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