Obstet Gynecol Sci.  2014 Mar;57(2):121-127.

Surgical impact on serum anti-Mullerian hormone in women with benign ovarian cyst: A prospective study

• Jang WK
• Lim SY
• Park JC
• Lee KR
• Lee A
• Rhee JH

Abstract

OBJECTIVE
The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated.
METHODS
In this prospective study, 22 patients of reproductive age (range, 18.35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis.
RESULTS
Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80-7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74-4.32) 3 months postoperation (P<0.05). On the other hand, no significant differences in FSH, E2, AFC and ovarian volumes were found between the preoperative and three months postoperative levels. In a subgroup analysis of the pathologic type of the ovarian cyst, postoperative serum AMH levels were significantly decreased in the endometrioma group, but not in the non-endometrioma group.
CONCLUSION
Serum AMH levels were significantly decreased after laparoscopic cystectomy without any changes of other ovarian reserve tests.

Keyword

Anti-Mullerian hormone; Benign ovarian mass; Endometrioma; Laparoscopic cystectomy

MeSH Terms

Anti-Mullerian Hormone*
Cystectomy
Endometriosis
Estradiol
Female
Follicle Stimulating Hormone
Follicular Phase
Hand
Humans
Ovarian Cysts*
Prospective Studies*
Anti-Mullerian Hormone
Estradiol
Follicle Stimulating Hormone