Nutr Res Pract.
2015 Oct;9(5):472-479. 10.4162/nrp.2015.9.5.472.
Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
- Affiliations
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- 1Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, Korea.
- 2Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea.
- 3Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University, 63 Beon-gil 2, Busandaehag-ro, Geumjeong-gu, Busan 609-735, Korea. hanjs@pusan.ac.kr
- KMID: 2313867
- DOI: http://doi.org/10.4162/nrp.2015.9.5.472
Abstract
- BACKGROUND/OBJECTIVES
The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice.
MATERIALS/METHODS
For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w).
RESULTS
A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice.
CONCLUSIONS
These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
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