Nutr Res Pract.  2024 Feb;18(1):88-97. 10.4162/nrp.2024.18.1.88.

Daraesoon (shoot of hardy kiwi) mitigates hyperglycemia in db/db mice by alleviating insulin resistance and inflammation

• Choi HN
• Kim JI

• KMID: 2552284
• DOI: http://doi.org/10.4162/nrp.2024.18.1.88

Abstract

BACKGROUND/OBJECTIVES
Mitigating insulin resistance and hyperglycemia is associated with a decreased risk of diabetic complications. The effect of Daraesoon (shoot of hardy kiwi, Actinidia arguta) on hyperglycemia was investigated using a type 2 diabetes animal model.
MATERIALS/METHODS
Seven-week-old db/db mice were fed either an AIN-93G diet or a diet containing 0.4% of a 70% ethanol extract of Daraesoon, whereas db/+ mice were fed the AIN-93G diet for 7 weeks.
RESULTS
Consumption of Daraesoon significantly reduced serum glucose and blood glycated hemoglobin levels, along with homeostasis model assessment for insulin resistance in db/db mice. Conversely, Daraesoon elevated the serum adiponectin levels compared to the db/db control group. Furthermore, Daraesoon significantly decreased both serum and hepatic triglyceride levels, as well as serum total cholesterol levels. Additionally, consumption of Daraesoon resulted in decreased hepatic tumor necrosis factor-α and monocyte chemoattractant protein-1 expression.
CONCLUSIONS
These results suggest that hypoglycemic effect of Daraesoon is mediated through the improvement of insulin resistance and the downregulation of pro-inflammatory cytokine expression in db/db mice

Keyword

Actinidia arguta; insulin resistance; adiponectin; inflammation; db/db mice

Figure

• 

  Fig. 1 Protein expression of MCP-1 (A) and TNF-α (B) of the liver in db/db mice.Seven-week-old db/db mice were fed an AIN-93G diet or a diet containing 0.4% Daraesoon extract, whereas lean control group was offered the AIN-93G diet ad libitum for 7 weeks. Values represent mean ± SEM (n = 7).MCP-1, monocyte chemoattractant protein 1; TNF-α, tumor necrosis factor α; SEM, standard error of the mean.a,b,cEach bar that do not share a common letter are significantly different at P < 0.05.

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