Nucl Med Mol Imaging.
2016 Mar;50(1):80-84. 10.1007/s13139-015-0371-z.
FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis
- Affiliations
-
- 1Department of Nuclear Medicine, Hôpital Henri Mondor AP-HP, Paris-Est University, 51 Ave. du Mal de Lattre de Tassigny, F-94010 Créteil, France. axel.vandergucht@gmail.com, emmanuel.itti@hmn.aphp.fr
- 2Deparment of Neurology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil F-94010, France. m.aounsebaiti@gmail.com, anne-catherine.bachoud-levi@hmn.aphp.fr
- 3Department of Radiology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil F-94010, France. paul.kauv@hmn.aphp.fr
- 4Department of Nuclear Medicine, Hospital "La Timone", Assistance Publique des Hôpitaux de Marseille, Marseille F-13000, France. eric.guedj@ap-hm.fr
- 5Department of Pathology, H. Mondor Hospital, Assistance Publique-Hôpitaux de Paris/Paris-Est University, Créteil F-94010, France.jessieaouizerate@gmail.com, romain.gherardi@hmn.aphp.fr, francois-jerome.authier@hmn.aphp.fr
- 6Reference Center for Neuromuscular Disorders, H.Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil F-94010, France.
- 7INSERM U955-Team 10, Créteil F-94010, France.
- 8CHU Nancy, Nuclear Medecine & Nancyclotep Experimental Imaging Platform, Nancy F-54000, France.
- 9INSERM U955-Team 1, Créteil F-94010, France.
- KMID: 2313279
- DOI: http://doi.org/10.1007/s13139-015-0371-z
Abstract
- Brain Positron Emission Tomography/Computed Tomography with 18F-fluorodeoxyglucose (FDG PET/CT) was performed in a 44-year-old woman with marked cognitive impairment, diffuse myalgias, sensory, memory and visual disorders, and chronic fatigue, presenting with histopathological features of macrophagic myofasciitis (MMF) at deltoid muscle biopsy. Cerebromedullary Magnetic Resonance Imaging (MRI), electromyography, ophthalmic examination, and cerebrospinal fluid analysis were normal. Visual analysis of FDG PET/CT images showed an atypical pattern of hypometabolism, involving symmetrically the occipital cortex, temporal lobes, and limbic system (including in particular amygdalo-hippocampal complexes), and the cerebellum. Posterior cingulate cortex and parietal areas were preserved. This pattern was confirmed by a voxel-based procedure using Statistical Parametric Mapping (SPM12) that compared a patient's images to normal reference samples from six healthy subjects with adjustment to age obtained using the same PET/CT camera. These results provide a glucose metabolism substrate for cognitive complaints in patients with long-lasting aluminium hydroxide-induced MMF.
MeSH Terms
-
Adult
Aluminum Hydroxide
Biopsy
Brain*
Cerebellum
Cerebrospinal Fluid
Deltoid Muscle
Electromyography
Electrons
Fatigue
Female
Fluorodeoxyglucose F18
Glucose
Gyrus Cinguli
Humans
Limbic System
Magnetic Resonance Imaging
Memory
Metabolism
Myalgia
Neuroimaging
Positron-Emission Tomography and Computed Tomography
Rabeprazole
Temporal Lobe
Vision Disorders
Aluminum Hydroxide
Fluorodeoxyglucose F18
Glucose
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- When We Consider Neurolymphomatosis in Patient with Lumbosacral Plexopathy with an Extreme Leg Pain?
- Use of 18F-FDG PET/CT in Second Primary Cancer
- Marchiafava-Bignami Disease with Abnormal PET Findings: Case Report
- F-18 FDG PET/CT Finding in Solid Pseudo-papillary Tumor of the Pancreas 6 years After Initial Diagnosis
- A Case of Incidentally Detected Nasopharyngeal Tuberculosis on F-18 FDG PET/CT
