Nucl Med Mol Imaging.  2014 Dec;48(4):303-305. 10.1007/s13139-014-0290-4.

Brain MRI, Tc-99m HMPAO SPECT and F-18 FP-CIT PET/CT Findings in a Patient with Wilson Disease: A Case Report

• Kim S
• Song IU
• Chung YA
• Choi EK
• Oh JK

• KMID: 2313213
• DOI: http://doi.org/10.1007/s13139-014-0290-4

Abstract

A 34-year-old female had experienced head and hand tremors with a dystonic component for 8 months. Brain MRI showed T2 high signal intensity in the periaqueductal region, dorsal midbrain and dorsal upper pons. No abnormal uptake was noted on Tc-99m HMPAO SPECT or F-18 FP-CIT PET/CT. Wilson disease was diagnosed according to the 2008 consensus guideline from the American Association for the Study of Liver Disease and 2012 guideline from the European Association for the Study of the Liver. This case demonstrates T2 signal change in the basal ganglia, excluding the putamen, in a Wilson disease patient with relatively severe clinical findings, but normal Tc-99m HMPAO SPECT and F-18 FP-CIT PET/CT.

Keyword

Wilson disease; MRI; Tc-99mHMPAOSPECT; F-18 FP-CIT PET/CT

MeSH Terms

Adult
Basal Ganglia
Brain*
Consensus
Female
Hand
Head
Hepatolenticular Degeneration*
Humans
Liver
Liver Diseases
Magnetic Resonance Imaging*
Mesencephalon
Pons
Positron-Emission Tomography and Computed Tomography*
Putamen
Technetium Tc 99m Exametazime*
Tomography, Emission-Computed, Single-Photon*
Tremor
Technetium Tc 99m Exametazime