J Korean Pediatr Soc.  1999 Dec;42(12):1711-1716.

Usefulness of Brain Tc-99m HMPAO SPECT in Establishing Lateralization of Intractable Seizure in Children

• Ahn SH
• Rah YH
• Chung SJ
• Cho EH

Abstract

PURPOSE: To determine the role of Tc-99m HMPAO SPECT imaging in children with intractable seizure by evaluating the interictal period.
METHODS
We compared the EEG, CT and MRI medical records with those of Tc-99m HMPAO SPECT in 42 patients with intractable seizure referred to Kyunghee University Hospital, from April 1983 to September 1998, retrospectively.
RESULTS
Mean age was 8.3 years and male to female ratio was 2.5 : 1. Multiple surface EEG recordings were performed in 42 patients and EEG findings of all patients showed an epileptogenic focus, with the most common area of abnormal findings being the Lt. sides. Brain CT was performed in 23 out of 42 patients(54.8%), and 15 out of the 23 patients(65.2%) showed abnormal findings and the most common area of abnormal findings were both sides. Brain MRI was performed in 21 out of 42 patients(50.0%), and 14 of the 21 patients(66.6%) showed abnormalities and the most common area of abnormal findings were both sides. In 32 out of the 42 patients (76.2%), SPECT images showed abnormal cerebral perfusion, most common area of hypoperfusion were Lt. sides. In 10 out of 14 cases, there were lateralizing abnormalities on the same side shown in SPECT and EEG, CT or MRI findings.
CONCLUSION
We concluded that Tc-99m HMPAO SPECT seemed to be a useful tool in the evaluation of intractable seizure patients.

Keyword

Tc-99m HMPAO SPECT; Intractable seizure; Lateralization

MeSH Terms

Brain*
Child*
Electroencephalography
Female
Humans
Magnetic Resonance Imaging
Male
Medical Records
Perfusion
Retrospective Studies
Seizures*
Technetium Tc 99m Exametazime*
Tomography, Emission-Computed, Single-Photon*
Technetium Tc 99m Exametazime