Nat Prod Sci.  2015 Sep;21(3):196-204. 10.0000/nps.2015.21.3.196.

Chemical Constituents from Leaves of Acanthopanax henryi (II)

• Li Z
• Li XJ
• Kwon OK
• Wang X
• Zou QP
• Liu XQ
• Lee HK

• KMID: 2312896
• DOI: http://doi.org/10.0000/nps.2015.21.3.196

Abstract

Nineteen compounds, including one organic acid (1), one anthraquinone (2), one amide (3), and sixteen triterpenoid saponins (4 - 19) were isolated from the leaves of Acanthopanax henryi (Oliv.) Harms (Araliaceae). Their structures were determined on the basis of physicochemical properties and spectral analyses (HR-MS and NMR). Among them, compounds 2, 3, 7, 12 and 19 were new within Araliaceae. Compounds 4, 5, 9 - 11, 13, 14, 16 and 18 were reported for the first time from the Acanthopanax genus. Except for compounds 4 and 9, other compounds were isolated from A. henryi (Oliv.) Harms for the first time. The rare anthraquinone, compound 2, significantly decreased the production of NO and the levels of other inflammatory factors, such as TNF-alpha and IL-6, in lipopolysaccharide (LPS)-stimulated macrophages in a dose-dependent manner. This is the first time to report anti-inflammatory effect of this compound.

Keyword

Araliaceae; Acanthopanax henryi; Triterpenoid saponins; Anthraquinone; Nitric oxide; Anti-inflammatory

MeSH Terms

Eleutherococcus*
Araliaceae
Interleukin-6
Macrophages
Nitric Oxide
Saponins
Tumor Necrosis Factor-alpha
Interleukin-6
Nitric Oxide
Saponins
Tumor Necrosis Factor-alpha