Nat Prod Sci.  2023 Dec;29(4):263-267. 10.20307/nps.2023.29.4.263.

Chemical Constituents from the Leaves of Dischidia nummularia (Asclepiadaceae)

• Benu SM
• Riga R
• Juliawaty LD

• KMID: 2550561
• DOI: http://doi.org/10.20307/nps.2023.29.4.263

Abstract

The investigation of chemical constituents from Dischidia nummularia leaves, which belongs to the Asclepiadaceae family, resulted in five known compounds. Three compounds were suggested as triterpenoid derivatives, namely glutinol (1), α-amyrin (2) and friedelin (3). In addition, two other compounds were a steroid derivative (4), i.e., stigmast-5-ene-3β-ol (4) and a xanthone derivative, i.e., α-mangostin (5). The chemical structures of 1–5 were elucidated based on detailed analysis of NMR (1D and 2D) spectroscopic data and compared with literature data. Interestingly, compounds 1 and 5 were first obtained from the Asclepiadaceae family, while compound 2 was isolated for the first time from the Dischidia genus. The acetone crude extract and compounds 1–3 showed weak cytotoxicity against murine leukemia P-388 cells. After all, the current study is the first report of a phytochemical study of D. nummularia.

Keyword

Dischidia nummularia; Triterpenoid; Steroid; Xanthone; Cytotoxicity