Nat Prod Sci.  2015 Jun;21(2):98-103. 10.0000/nps.2015.21.2.98.

Effect of the Mixture of Pueraria lobata and Sorbus commixta Extract on the Alcohol-induced Hangover in Rats

• Hong SC
• Yoo JH
• Oh MH
• Lee H
• Park YS
• Parthasarathi S
• Park JD
• Pyo MK

• KMID: 2312880
• DOI: http://doi.org/10.0000/nps.2015.21.2.98

Abstract

Pueraiae Radix (PR), Pueratia Folium (PF) and Sorbus commixta (SC) mixture, namely GS-SP (PR (1)/PF (2)/SC (0.5): v/v/v) was developed as hangover-relieving elixir and its effects on alcoholic metabolism have been investigated. The enzymatic activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) of GS-SP was shown higher than those of single treatment with PR, PL, SC, and the positive control group (YM-808). The survival rate of mouse liver cell line NCTC clone 1469 in the presence of acetaldehyde was 30.6, 22.2, and 8.7% at the GS-SP dosage level of 50, 100, and 200 microg/mL respectively. Different concentrations of 50, 100 and 200 mg/kg of GS-SP showed efficient activity for ADH and ALDH than YM-808 in rat fed with 25% ethanol. The levels of blood alcohol and acetaldehyde after oral administration of 200 mg/kg of GS-SP showed efficient activity of 11.7% and 37% than those of YM-808. These results have been supported to the potential for GS-SP to serve as an excellent potential in providing hangover relief and liver protection.

Keyword

Pueraiae lobata; Sorbus commixta; Alcohol dehydrogenase; Acetaldehyde dehydrogenase; Hangover

MeSH Terms

Acetaldehyde
Administration, Oral
Alcohol Dehydrogenase
Alcoholics
Animals
Cell Line
Clone Cells
Ethanol
Humans
Liver
Metabolism
Mice
Oxidoreductases
Pueraria*
Rats*
Sorbus*
Survival Rate
Acetaldehyde
Alcohol Dehydrogenase
Ethanol
Oxidoreductases