Korean J Vet Res.  2016 Dec;56(4):241-247. 10.14405/kjvr.2016.56.4.241.

Hangover relieving effect of Sanghwang mushroom mycelium extract

• Kim MS
• An YJ
• Lee JC
• Park GR
• Park DS
• Jeon NG
• Lee Y
• Han CH

• KMID: 2368776
• DOI: http://doi.org/10.14405/kjvr.2016.56.4.241

Abstract

This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity (56.67 ± 1.77%) when administered at 120 µg/mL. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity (126.03 ± 9.11%) when applied at 8 or 16 µL/mL. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol (120.13 ± 12.83 µg/mL) and aldehyde (7.26 ± 1.22 µg/mL) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.

Keyword

blood aldehyde concentration; hangover relieving effect; locomotor activity test; Sanghwang mushroom mycelium extract