Mycobiology.
2010 Mar;38(1):46-51.
The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage
- Affiliations
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- 1Department of Microbiology, Dong-A University College of Medicine, Busan 604-714, Korea. mhjeong@dau.ac.kr
- 2Cheong-Won Farm, Gimhae 621-843, Korea.
- 3Deartment of Microbiology, Pusan National University College of Natural Sciences, Busan 609-735, Korea.
Abstract
- The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-alpha and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.