Lab Anim Res.  2010 Jun;26(2):153-164. 10.5625/lar.2010.26.2.153.

Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies

• Han ZZ
• Xu HD
• Kim KH
• Ahn TH
• Bae JS
• Lee JY
• Gil KH
• Lee JY
• Woo SJ
• Yoo HJ
• Lee HK
• Kim KH
• Park CK
• Zhang HS
• Song SW

• KMID: 2312061
• DOI: http://doi.org/10.5625/lar.2010.26.2.153

Abstract

The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to "the standards of Toxicity Study for Medicinal Products" (2005) and The KFDA Notification No. 2000-63 'Good Laboratory Practice (GLP)' (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.

Keyword

Hematology; reference data; Sprague-Dawley rat; pre-clinical toxicity studies

MeSH Terms

Biochemistry
Body Weight
Hematology
Organ Size
Rats, Sprague-Dawley
Urinalysis
Water
Water

Figure

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  Figure 1. Reference data of mean body weights from 4- and 13-week toxicity studies in male and female Sprague-Dawley rats

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  Figure 2. Reference data of food consumption from 4- and 13-week toxicity studies in male and female Sprague-Dawley rats

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  Figure 3. Reference data of water consumption from 4- and 13-week toxicity studies in male and female Sprague-Dawley rats

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