Lab Anim Res.  2012 Jun;28(2):115-121. 10.5625/lar.2012.28.2.115.

Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats

• Lee JM
• Lee MA
• Do HN
• Song YI
• Bae RJ
• Lee HY
• Park SH
• Kang JS
• Kang JK

• KMID: 1436707
• DOI: http://doi.org/10.5625/lar.2012.28.2.115

Abstract

Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 11 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 5 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gamma-glutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.

Keyword

Crj:CD (SD) rat; control data; reference range; toxicology

MeSH Terms

Animals
Basophils
Bilirubin
Body Weight
Eosinophils
gamma-Glutamyltransferase
Humans
Male
Organ Size
Rats
Reference Values
Sprains and Strains
Toxicology
Urinalysis
Uterus
Bilirubin
gamma-Glutamyltransferase

Figure

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  Figure 1 Changes in body weight of male and female rats

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  Figure 2 Changes in food consumption of male and female rats

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