Korean J Neurogastroenterol Motil.  2007 Dec;13(2):104-110.

The Effect of Visceral Adipose Tissue on the Contractility of Rabbit Gastric Antral Smooth Muscle

Affiliations
  • 1Department of Physiology, Chung-Ang University College of Medicine, Seoul, Korea. heeyun@cau.ac.kr

Abstract

BACKGROUND/AIMS: Some investigators reported that the adipose tissues might affect the contractilityof some vascular smooth muscle. We aimed to demonstrate the effects of adipose tissue in the viscera on the contractile response of rabbit gastric smooth muscle.
METHODS
New Zealand White rabbits, around 2.5 kg, were used for the experiments. They were anesthetized with urethane then the antral portion of stomach has been taken and prepared, using force transducer to record itscontractility.
RESULTS
Acetylcholine (ACh) and highly concentrated potassium (K) induced dose-dependentcontractions of the strip. This contractile response was divided into tonic and phasic components and the phasic component was more prominent at high K-induced contraction. Norepinephrine (NE) revealed concentration-dependent relaxation when tonic contraction was induced by 10 mM ACh. Adipose tissues induced weight-dependent relaxations on the both of tonic contractions induced by ACh and/or high K. Adipose tissues did not evoke any remarkable changes on phasic contraction and NE-induced relaxation.
CONCLUSIONS
It is likely that the adipose tissue in viscera seem to be affectingthe contractility of gastric smooth muscle via Ca channel inhibitory mechanism.

Keyword

Adipose tissue; Ca channel; Contractility; Stomach

MeSH Terms

Acetylcholine
Adipose Tissue
Humans
Intra-Abdominal Fat*
Muscle, Smooth*
Muscle, Smooth, Vascular
Norepinephrine
Potassium
Rabbits
Relaxation
Research Personnel
Stomach
Transducers
Urethane
Viscera
Acetylcholine
Norepinephrine
Potassium
Urethane
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