Korean J Nephrol.
2009 Nov;28(6):639-642.
A Case of Successful Hemoperfusion in the Treatment of Acute Severe Clozapine Intoxication
- Affiliations
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- 1Division of Nephrology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. eylee@sch.ac.kr
Abstract
- Clozapine, a psychotropic drug commonly used in the treatment of schizophrenia or schizophrenic affective disorders may show side effects such as agranulocytosis, cardiomyositis, cognitive and motor depression in therapeutic doses and central nervous system depression, respiratory depression, arrhythmia, seizures, and even death in case of severe intoxication, warranting an aggressive treatment. We hereby report a case of clozapine overdose patient who ingested a potentially fatal dose of 3 grams and showed stuporous mental state, who was treated successfully by hemoperfusion without any sequelae.
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