Korean J Hepatobiliary Pancreat Surg.
2010 Dec;14(4):262-266.
A Case of Liver Metastasis of Gastrointestinal Stromal Tumor That Was Resected after Treatment with Imatinib Mesylate and Sunitinib
- Affiliations
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- 1Department of Surgery, Wonkwang University Hospital, Wonkwang University College of Medicine, Korea. chaekm@wonkwang.ac.kr
- 2Department of Hemato-Oncology, Wonkwang University Hospital, Wonkwang University College of Medicine, Korea.
- 3Department of Radiology, Wonkwang University Hospital, Wonkwang University College of Medicine, Korea.
- 4Department of Pathology, Wonkwang University Hospital, Wonkwang University College of Medicine, Korea.
Abstract
- A 65-year old man underwent wedge resection for a gastrointestinal stromal tumor (GIST) of the gastric fundus in 1997. In 2003, the abdominal CT and sono-guided biopsy revealed he had a large GIST liver metastasis. He underwent treatment with 400 mg/day of imatinib mesylate. As a result, the liver metastasis markedly decreased in size. However, focal progression of the liver metastasis was observed on the follow up CT, so we increased the imatinib from 400 mg/day to 800 mg/day. We then performed extended left hepatectomy. We report here on a patient who presented with an isolated metastatic GIST to the liver, and the patient was successfully treated with imatinib therapy and hemihepatectomy.