Therapeutic Effect of Silatranes on Mouse Skin Ulcers

Kang, Jung Dae; Kim, So jin; Park, Seok Don

Abstract

BACKGROUND
Silicon compounds, especially silatranes, are known to stimulate the regeneration of connective tissue, especially collagen. This has led to a great deal of research on the effects that new silatranes have on wound healing. OBJECTIVE: The purpose of this study is to compare efficacies of new silatrane ointments, an ointment-base (vaseline-lanoline), and a mupirocin ointment (Bactroban(R)) on ulcer healing. METHODS: Two groups of mice, composed of 10 mice each, were included in this study. Three ulcers were made on the back of each mouse and ointments were applied twice daily. For each mouse of Group I, silatrane ointment (-vinyl) was applied to the first ulcer, the ointment-base (vaseline-lanoline) to the second, and the mupirocin ointment (Bactroban(R)) to the third. Ointments were applied to the mouse of Group II in the same manner using silatranes ointment (-allyl), the ointment-base, and the mupirocin ointment. We compared the time it took for each ulcer to heal, the percent change over time of the wound area from baseline (as a reduction of percentage area), and mean healing rate. RESULTS: The results are as follows: 1. Two silatrane ointments (-vinyl, -allyl) brought about a faster healing time than either the ointment-base or the mupirocin ointment did. 2. Two silatrane ointments led to a greater reduction in the percentage area from baseline over time than the ointment-base and the mupirocin ointment. 3. Two silatrane ointments provided better results in terms of total area healed per day during the first 7 days than the ointment-base and mupirocin ointment did. CONCLUSION: Two Silatrane ointments (-vinyl, -allyl) are effective in the treatment of mouse skin ulcers.