Korean J Dermatol.  2014 Dec;52(12):895-899.

Leser-Trelat Sign Associated with Malignant Melanoma

• Lee DY
• Baek JH
• Kim DJ
• Kim MS
• Lee UH
• Park HS

Abstract

Leser-Trelat sign is a rare paraneoplastic dermatosis that is characterized by the eruptive and rapid development of multiple seborrheic keratosis that coincides with an internal malignancy. Eruptive seborrheic keratosis can be pruritic and appear in a "Christmas-tree pattern." This sign occurs in association with a number of cancers, such as adenocarcinoma of the gastrointestinal tract and various lymphoproliferative disorders. However, Leser-Trelat sign associated with a malignant melanoma is very rare. A 58-year-old male patient presented with an asymptomatic black mass on the penile orifice and patch on the glans penis. He complained of gross hematuria. At the same time, he developed asymptomatic multiple brown papules and plaques on the back. The histopathologic findings of the glans and back lesions were consistent with malignant melanoma and seborrheic keratosis, respectively. Here, we describe a rare case of Leser-Trelat sign associated with malignant melanoma.

Keyword

Leser-Trelat sign; Melanoma; Seborrheic keratosis

MeSH Terms

Adenocarcinoma
Gastrointestinal Tract
Hematuria
Humans
Keratosis, Seborrheic
Lymphoproliferative Disorders
Male
Melanoma*
Middle Aged
Penis
Skin Diseases