Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta
- Affiliations
-
- 1Department of Anesthesiology and Pain Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
- 2Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea.
- 3Department of Oral and Maxillofacial Surgery, Gyeongsang National University Hospital, Jinju, Korea.
- 4Department of Anesthesiology and Pain Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea. jtsohn@nongae.gsnu.ac.kr
- KMID: 2299374
- DOI: http://doi.org/10.4097/kjae.2013.64.4.353
Abstract
- BACKGROUND
Intravenous lipid emulsion has been used to treat systemic toxicity of local anesthetics. The goals of this in vitro study were to determine the ability of two lipid emulsions (Intralipid(R) and Lipofundin(R) MCT/LCT) to reverse toxic dose local anesthetic-induced vasodilation in isolated rat aortas.
METHODS
Isolated endothelium-denuded aortas were suspended for isometric tension recording. Vasodilation was induced by bupivacaine (3 x 10(-4) M), ropivacaine (10(-3) M), lidocaine (3 x 10(-3) M), or mepivacaine (7 x 10(-3) M) after precontraction with 60 mM KCl. Intralipid(R) and Lipofundin(R) MCT/LCT were then added to generate concentration-response curves. We also assessed vasoconstriction induced by 60 mM KCl, 60 mM KCl with 3 x 10(-4) M bupivacaine, and 60 mM KCl with 3 x 10(-4) M bupivacaine plus 1.39% lipid emulsion (Intralipid(R) or Lipofundin(R) MCT/LCT).
RESULTS
The two lipid emulsions reversed vasodilation induced by bupivacaine, ropivacaine, and lidocaine but had no effect on vasodilation induced by mepivacaine. Lipofundin(R) MCT/LCT was more effective than Intralipid(R) in reversing bupivacaine-induced vasodilation. The magnitude of lipid emulsion-mediated reversal of vasodilation induced by high-dose local anesthetics was as follows (from highest to lowest): 3 x 10(-4) M bupivacaine-induced vasodilation, 10(-3) M ropivacaine-induced vasodilation, and 3 x 10(-3) M lidocaine-induced vasodilation.
CONCLUSIONS
Lipofundin(R) MCT/LCT-mediated reversal of bupivacaine-induced vasodilation was greater than that of Intralipid(R); however, the two lipid emulsions equally reversed vasodilation induced by ropivacaine and lidocaine. The magnitude of lipid emulsion-mediated reversal of vasodilation appears to be correlated with the lipid solubility of the local anesthetic.
Keyword
MeSH Terms
Cited by 3 articles
-
Lipid emulsion treatment of systemic toxicity induced by local anesthetics or other drugs
Il-Woo Shin, Ju-Tae Sohn
J Korean Med Assoc. 2014;57(6):537-544. doi: 10.5124/jkma.2014.57.6.537.Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine
Seong Ho Ok, Sung Il Bae, Seong Chun Kwon, Jung Chul Park, Woo Chan Kim, Kyeong Eon Park, Il Woo Shin, Heon Keun Lee, Young Kyun Chung, Mun Jeoung Choi, Ju Tae Sohn
Korean J Pain. 2014;27(3):229-238. doi: 10.3344/kjp.2014.27.3.229.Lipid emulsion inhibits vasodilation induced by a toxic dose of bupivacaine by suppressing bupivacaine-induced PKC and CPI-17 dephosphorylation but has no effect on vasodilation induced by a toxic dose of mepivacaine
Hyunhoo Cho, Seong Ho Ok, Seong Chun Kwon, Soo Hee Lee, Jiseok Baik, Sebin Kang, Jiah Oh, Ju-Tae Sohn
Korean J Pain. 2016;29(4):229-238. doi: 10.3344/kjp.2016.29.4.229.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Lipid Emulsions Enhance the Norepinephrine-Mediated Reversal of Local Anesthetic-Induced Vasodilation at Toxic Doses
- Lipid emulsion inhibits vasodilation induced by a toxic dose of bupivacaine by suppressing bupivacaine-induced PKC and CPI-17 dephosphorylation but has no effect on vasodilation induced by a toxic dose of mepivacaine
- Lipid emulsion treatment of systemic toxicity induced by local anesthetics or other drugs
- Lipid Emulsion in the Successful Resuscitation of Local Anesthetic Toxicity after Ankle Block
- Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine
