Korean J Anesthesiol.  2001 Jan;40(1):34-40. 10.4097/kjae.2001.40.1.34.

The Effects of Intravenous Thiopental Injection on Jugular Venous Oxygen Saturation (SjVO2) during Cerebral Aneurysm Surgery

• Moon BK
• Jung SM
• Han SG
• Ahn YM
• Cho KG
• Min SK
• Kim DM
• Han JS
• Lee YJ
• Kim JS

• KMID: 2298968
• DOI: http://doi.org/10.4097/kjae.2001.40.1.34

Abstract

BACKGROUND: Thiopental has a profound impact on the cardiovascular system. The effects of hemody namics after intravenous thiopental on the balance of cerebral metabolism with cerebral blood flow is unknown. The purpose of this study was to monitor hemodynamic change, cerebral arterial-jugular venous oxygen content difference (AVDO2) and jugular venous oxygen saturation (SjVO2) after a thiopental injection for brain protection during cerebral aneurysm surgery.
METHODS
Twenty patients received a standard anesthetic consisting of isoflurane, vecuronium and fentanyl with a PaCO2 of 30 35 mmHg. Hemodynamics, arterial and jugular venous blood gases were measured at 3 time points:I; Just before thiopental injection; II; Electroencephalographic (EEG) burst suppression after a 4 5 mg/kg intravenous thiopental injection; and III; EEG recovery.
RESULTS
Intravenous thiopental (4 5 mg/kg) induced an EEG burst suppression for 6.5 +/- 1.7 minutes. Hemodynamics and arterial blood gas analysis were not significantly different among the different time points, but mean arterial pressure (68.4 +/- 7.2 mmHg) and systemic vascular resistance (1027.0 +/- 300.9 dynes sec/cm5) in II were significantly (P < 0.05) decreased compared with I (84.3 +/- 9.6, 1169.1 +/- 304.5) and III (89.1 +/- 10.6, 1288.6 +/- 426.1). SjVO2 (71.6 +/- 11.8%) was significantly (p < 0.05) decreased within the normal value compared with I (75.1 +/- 5.6) and III (76.1 +/- 10.1), but AVDO2 was not significantly different among the 3 time points. There was no evidence of cerebral ischemia or infarction in computed tomographic (CT) findings of the 20 patients after surgery.
CONCLUSIONS
Hemodynamics after 4 5 mg/kg intravenous thiopental do not modify the balance ofcerebral oxygen metabolism with cerebral blood flow in patients undergoing cerebral aneurysm surgery.

Keyword

Anesthetics, intravenous: thiopental; Brain: cerebral arterial-jugular venous oxygen content difference, jugular venous oxygen saturation; Surgery: cerebral aneurysm

MeSH Terms

Arterial Pressure
Blood Gas Analysis
Brain
Brain Ischemia
Cardiovascular System
Electroencephalography
Fentanyl
Gases
Hemodynamics
Humans
Infarction
Intracranial Aneurysm*
Isoflurane
Metabolism
Oxygen*
Reference Values
Thiopental*
Vascular Resistance
Vecuronium Bromide
Fentanyl
Gases
Isoflurane
Oxygen
Thiopental
Vecuronium Bromide