Korean J Urol.  2001 Sep;42(9):971-977.

Changes of Serum Androgen and Bone Mineral Density in Korean Aging Male

• Kim DS
• Kim YH
• Lee NK

Abstract

PURPOSE: Osteoporosis is generally regarded as disease of women and there are extensive data about post-menopausal osteopotosis, but there is relatively little information concerning the osteoporosis in aging male. We aimed to determine the relationships between age ,androgen and bone mineral density (BMD) in elderly korean men.
MATERIALS AND METHODS
We evaluated the sex hormones and BMD of 82 elderly men between May 1999 and April 2000. Serum free testosterone (FT), total testosterone (TT), DHT, LH, FSH and Prolactin were measured by RIA. BMD at anteroposterior L2-4, femoral neck, ward's triangle, femoral trochanter and femoral shaft were determined by dual-energy X-ray absorptiometry. We defined group I as free testosterone <10ng/dl and group II as 10ng/dl.
RESULTS
Serum LH and FSH increased with age. There was a significant decrease in serum FT with age, but T concentrations remained unchanged. There were significant declines with age in BMD at femoral neck, Ward's triangle, femoral trochanter, femoral shaft. Serum FT were significantly correlated to BMD at anteroposterior L2-4, femoral neck, Ward's triangle, femoral trochanter, femoral shaft. After controlling for age, serum FT were significantly correlated to BMD at femoral trochanter, femoral shaft. Mean BMD was significantly lower in group I than group II at anteroposterior L2-4, femoral shaft.
CONCLUSIONS
We suggest that FT is a male osteoporotic marker in man older than 50 years and bone mineral density should be considered for diagnosis of male osteoporosis associated with PADAM, especially when FT is lower than 10ng/dl.

Keyword

Aging; Male; Androgen; Bone mineral density; Osteoporosis

MeSH Terms

Absorptiometry, Photon
Aged
Aging*
Bone Density*
Diagnosis
Female
Femur
Femur Neck
Gonadal Steroid Hormones
Humans
Male*
Osteoporosis
Prolactin
Testosterone
Gonadal Steroid Hormones
Prolactin
Testosterone