Korean J Urol.  1997 Jul;38(7):683-687.

Histologic and Functional Alteration in the Prostate and in the Seminal Vesicle of Rat with Streptozotocin-induced Diabetes

• Ryu I
• Cho JS

Abstract

Our investigation was performed to define the effects of diabetes on the prostate and the seminal vesicle in the male rat. The histologic and functional alterations of the prostate and the seminal vesicle were examined in the control and the streptozotocin-induced diabetic rats. The most striking findings were the variable reduction in size and the gross atrophy of the prostates and the seminal vesicles from diabetic rats. Diabetic rats experienced a significant loss in total body weight relative to controls. The weight of the prostates and the seminal vesicles was markedly reduced in diabetic rats relative to controls and the rate of weight reduction of the prostate and the seminal vesicle was more severe than that of total body weight reduction. Prostate specific antigen was significantly reduced but seminal fructose was elevated in the diabetic rat. In the prostate and the seminal vesicle of the diabetic rat, there are both histologic and functional abnormalities which may be responsible for reproductive dysfunction.

Keyword

Streptozotocin; Diabetes; Rat; Prostate; Seminal vesicle

MeSH Terms

Animals
Atrophy
Body Weight
Fructose
Humans
Male
Prostate*
Prostate-Specific Antigen
Rats*
Seminal Vesicles*
Streptozocin
Strikes, Employee
Weight Loss
Fructose
Prostate-Specific Antigen
Streptozocin