Experimental Seminal Vesiculitis Induced by Repeated Injections of Homologous and Heterologous Seminal Vesicle Tissue

Hurh, Yong

Abstract

An experiment on seminal vesiculitis in rats induced by repeated injections of homologous and heterologous seminal vesicle tissue suspension with Freund's complete adjuvant was accomplished to produce an immune disease in the seminal vesicle for the purpose to find the cause of same type of lesion in human beings were divided into 7 In this study 65 healthy adult white rats which weighed from 150 to 250 gm. were divided into 7 groups are follows: Group 1. Six rats, control, injected with normal saline Group 2. Six rats, injected with adjuvant Group 3. Seven rats, injected with seminal vesicle tissue suspension Group 4. Six rats, injected with rat seminal vesicle tissue suspension and adjuvant with prednisolone Group 5. Seven rats, injected with rabbit seminal vesicle tissue suspension Group 6. Seven rats, injected with rabbit seminal vesicle tissue suspension with adjuvant. Rats in these 6 groups were injected weekly for 8 weeks and sacrificed on the sixty fourth day. Group 7. Twenty-six rate, rat seminal vesicle tissue suspension with adjuvant. Rats in this group were subdivided into four groups Group A. Five rats, injected 4 times and sacrificed on 64th day. Group B. Seven rats, injected 6 times and sacrificed on 64th day. Group C. Seven rats, injected 8 times and sacrificed on 64th day. Group D. Seven rats. injected 8 times and sacrificed on 92nd day. Seminal vesicles from all the rats sacrificed were histopathologically studied and results were obtained as follows. Significant histopathologic alterations suck as glandular atrophy, decreased secretoryactivity, interstitial fibrosis, edema. congestion and inflammatory cellinfiltration suggesting of noninfectious chronic seminal vesiculitis were obtained in most rats of Group 7. Severity of inflammatory reaction seemed to be accentuated according to the increase of frequency of the date of sacrifice not concerned. Those allergic reaction were appeared to be inhibited by administration of prednisolone.