J Gynecol Oncol.  2013 Jul;24(3):287-290. 10.3802/jgo.2013.24.3.287.

Neoadjuvant chemotherapy followed by fertility-sparing surgery for women with stage IB1 cervical cancer

Affiliations
  • 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China. xiangyang65@gmail.com

Abstract

Fertility-sparing surgery was optimal to patients with tumor diameter smaller than 2 cm. For patients with larger tumors, neoadjuvant chemotherapy can debulk the tumor and offer the chance of surgery. We report 2 cases of stage IB1 cervical cancer treated by neoadjuvant chemotherapy and fertility-sparing surgery. Relevant literature was reviewed. Its safety, efficacy, and reproductive outcome need to be validated in the future.

Keyword

Fertility-sparing surgery; Neoadjuvant chemotherapy; Uterine cervical neoplasms

MeSH Terms

Female
Humans
Uterine Cervical Neoplasms

Reference

1. Dargent D, Burn JL, Roy M, Remi I. Pregnancies following radical trachelectomy for invasive cervical cancer. Gynecol Oncol. 1994; 52:105.
2. Kobayashi Y, Akiyama F, Hasumi K. A case of successful pregnancy after treatment of invasive cervical cancer with systemic chemotherapy and conization. Gynecol Oncol. 2006; 100:213–215.
3. Plante M, Lau S, Brydon L, Swenerton K, LeBlanc R, Roy M. Neoadjuvant chemotherapy followed by vaginal radical trachelectomy in bulky stage IB1 cervical cancer: case report. Gynecol Oncol. 2006; 101:367–370.
4. Landoni F, Parma G, Peiretti M, Zanagnolo V, Sideri M, Colombo N, et al. Chemo-conization in early cervical cancer. Gynecol Oncol. 2007; 107:S125–S126.
5. Liu H, Peng ZL, Lou JY, Ping W. Pregnancy after neoadjuvant chemotherapy followed by pelvic lymphadenectomy and radical trachelectomy in bulky stage IB1 cervical cancer: a case report. Aust N Z J Obstet Gynaecol. 2008; 48:517–518.
6. Maneo A, Chiari S, Bonazzi C, Mangioni C. Neoadjuvant chemotherapy and conservative surgery for stage IB1 cervical cancer. Gynecol Oncol. 2008; 111:438–443.
7. Rob L, Pluta M, Strnad P, Hrehorcak M, Chmel R, Skapa P, et al. A less radical treatment option to the fertility-sparing radical trachelectomy in patients with stage I cervical cancer. Gynecol Oncol. 2008; 111:S116–S120.
8. Robova H, Halaska M, Pluta M, Skapa P, Strnad P, Lisy J, et al. The role of neoadjuvant chemotherapy and surgery in cervical cancer. Int J Gynecol Cancer. 2010; 20:S42–S46.
9. Singh P, Nicklin J, Hassall T. Neoadjuvant chemotherapy followed by radical vaginal trachelectomy and adjuvant chemotherapy for clear cell cancer of the cervix: a feasible approach and review. Int J Gynecol Cancer. 2011; 21:137–140.
10. Gottschalk E, Mangler M, Schneider A, Koehler C, Lanowska M. Pregnancy after lymphadenectomy and neoadjuvant chemotherapy followed by radical vaginal trachelectomy in FIGO stage IB1 cervical cancer. Fertil Steril. 2011; 95:2431.e5. 2431.e7.
11. Marchiole P, Tigaud JD, Costantini S, Mammoliti S, Buenerd A, Moran E, et al. Neoadjuvant chemotherapy and vaginal radical trachelectomy for fertility-sparing treatment in women affected by cervical cancer (FIGO stage IB-IIA1). Gynecol Oncol. 2011; 122:484–490.
12. Palaia I, Musella A, Loprete E, Achilli C, Perniola G, Panici PB. Neoadjuvant chemotherapy plus fertility-sparing surgery in locally advanced cervical cancer: case report. J Minim Invasive Gynecol. 2011; 18:121–122.
13. Robova H, Pluta M, Hrehorcak M, Skapa P, Rob L. High-dose density chemotherapy followed by simple trachelectomy: full-term pregnancy. Int J Gynecol Cancer. 2008; 18:1367–1371.
14. Kim HS, Kim JY, Park NH, Kim K, Chung HH, Kim YB, et al. Matched-case comparison for the efficacy of neoadjuvant chemotherapy before surgery in FIGO stage IB1-IIA cervical cancer. Gynecol Oncol. 2010; 119:217–224.
15. Marth C, Sundfor K, Kaern J, Trope C. Long-term follow-up of neoadjuvant cisplatin and 5-fluorouracil chemotherapy in bulky squamous cell carcinoma of the cervix. Acta Oncol. 1999; 38:517–520.
16. Cao DY, Yang JX, Shen K, Xiang Y, Pan LY, Lang JH, et al. Comparison of effectiveness between intra-arterial and intra-venous neoadjuvant chemotherapy in stage Ib2-IIb cervical carcinoma. Zhonghua Fu Chan Ke Za Zhi. 2008; 43:888–891.
Full Text Links
  • JGO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr