Korean J Psychopharmacol.
1997 Apr;8(1):48-54.
Estrogen and Alzheimer's Disease
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Kon-Kuk University, Chungju, Korea.
- 2Department of Psychiatry, Yong-Dong Severence Hospital, College of Medicine, Yonsei University, Seoul, Kroea.
Abstract
- Aging of the population in industrialized countries, as a result of increased life expectancy, is known to be associated with an increased risk of dementia, especially Alzheimer's disease. Estrogen use by postmentopausal women has been reported to have favorable effects on health, cognitive function, and prevention of Alzheimer's disease in old age, which now represents a revitalized area of clinical research. And may investigator reported that estrogen promotes the growth and survival of cholinergic neurons and could decrease cerebral amyloid deposition, both of which may delay the onset or prevent Alzheimer's disease. But more propective studies are needed to establish the dose and duration of estrogen required to provide these benefits and to assess its safety in elderly postmentopausal women.
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