J Korean Med Assoc.  2009 Apr;52(4):417-425. 10.5124/jkma.2009.52.4.417.

Evidence-Based Treatment of Alzheimer's Disease

Affiliations
  • 1Department of Psychiatry, Inje University College of Medicine, Korea.
  • 2Department of Psychiatry, Seoul National University College of Medicine, Korea. kwkimmd@snu.ac.kr

Abstract

The pharmacological treatment of Alzheimer's disease is based on symptomatic therapy of cognitive decline and behavioral problems. Numerous therapies have been investigated for the treatment and prevention of Alzheimer's disease. We reviewed the current evidence-based medical research and guidelines of treatment for Alzheimer's disease. The use of cholinesterase inhibitors (ChEI) and N-methyl-D-aspartate (NMDA) inhibitors can bring about significant but modest therapeutic improvement. There is insufficient evidence to recommend vitamine E, estrogen, ginko biloba, or nonsteroidal anti-inflammatory drugs (NSAIDs) for the prevention or treatment of Alzheimer's disease. This article reviews the available data on current pharmacological treatments through evidence-based medicine.

Keyword

Alzheimer's disease; Pharmacotherapy; Cholinesterase inhibitor; Memantine; Evidence

MeSH Terms

Alzheimer Disease
Cholinesterase Inhibitors
Estrogens
Evidence-Based Medicine
Ginkgo biloba
Memantine
N-Methylaspartate
Vitamins
Cholinesterase Inhibitors
Estrogens
Memantine
N-Methylaspartate
Vitamins
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