Korean J Psychopharmacol.
2005 Jul;16(4):317-323.
Association Study of the Catechol-O-Methyltransferase Gene Polymorphism in ADHD in Korean Population
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea. paperose@dku.edu
- 2Department of Child and Adolescent Psychiatry, Seoul National University Hospital, Seoul, Korea.
- 3Cell Biology Laboratory, Korean Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
- 4Research Institute of Natural Sciences, Sookmyung Women's University, Seoul, Korea.
- 5Department of Clinical Pathology, College of Medicine, Dankook University, Cheonan, Korea.
- 6Department of Psychiatry, College of Medicine, Chonbuk National University, Chonju, Korea.
Abstract
OBJECTIVE
Attention deficit hyperactivity disorder is known to be a disorder with high genetic trait. Recently the relationship between alleles frequency distribution and ADHD, has been actively researched. In Korea, the relationship between the genetic type and alleles for COMT (Catechol-O-methyltransferase) gene, has been studied in ADHD patients. METHODS: Thirty three patients diagnosed with ADHD according to the DSM-IV diagnostic criteria were selected for the study. The diagnosis and clinical features were confirmed by Korean version Child behavior check list, Korean version Conner's parent rating scale, Attention deficit Diagnostic System, Korean version Spielberger state-trait anxiety scale etc. For the control group, the parents of patients were chosen. Blood samples were taken from the 99 subjects. DNA was extracted from blood lymphocytes, PCR was performed for COMT NlaIII VNTR Polymorphism. Allele and genotype frequencies were compared using the Chi-square test. For the family-based analyses, we used the TDT and HHRR method. RESULTS AND CONCLUSION: In comparing the ADHD transmitted group and the not transmitted group, No significant difference was seen between the COMT genetic type and alleles distribution. As a result, it is viewed that there is not relationship between ADHD and the dopamine transporter gene, but final decision is indefinite. Follow up studies with larger patient or pure subgroups are expected.
MeSH Terms
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Alleles
Anxiety
Attention Deficit Disorder with Hyperactivity
Catechol O-Methyltransferase*
Child
Child Behavior
Diagnosis
Diagnostic and Statistical Manual of Mental Disorders
DNA
Dopamine Plasma Membrane Transport Proteins
Genotype
Humans
Korea
Lymphocytes
Parents
Polymerase Chain Reaction
Catechol O-Methyltransferase
DNA
Dopamine Plasma Membrane Transport Proteins
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