- Impaired Set-Shifting Ability in Patients with Eating Disorders, Which Is Not Moderated by Their Catechol-O-Methyltransferase Val158Met Genotype
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Kim YR, Kim JE, Kim MH
- KMID: 2315918
- Psychiatry Investig.
- 2010 Dec;7(4):298-301.
The aim of this study was to examine the set-shifting ability in women with both anorexia nervosa (AN) and bulimia nervosa (BN) and to investigate whether it is contributed by... -
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- The Catechol-O-Methyltransferase Val158Met Polymorphism Contributes to the Risk of Breast Cancer in the Chinese Population: An Updated Meta-Analysis
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Wan GX, Cao YW, Li WQ, Li YC, Li F
- KMID: 2353070
- J Breast Cancer.
- 2014 Jun;17(2):149-156.
PURPOSE: Catechol-O-methyltransferase (COMT) enzyme plays a central role in estrogen-induced carcinogenesis. Emerging evidence from association studies has revealed that the functional Val158Met polymorphism (rs4680 G>A) of the Catechol-O-methyltransferase gene (COMT)... -
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- Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura
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Park JW, Lee KS, Kim JS, Kim YI, Shin HE
- KMID: 1700683
- J Clin Neurol.
- 2007 Mar;3(1):24-30.
- doi: 10.3988/jcn.2007.3.1.24
BACKGROUND: Recent genetic association studies have investigated the possible genetic role of the dopaminergic system in migraine. Catechol-O-methyltransferase (COMT) is an enzyme that plays a crucial role in the metabolism... -
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- Association of the Catechol-o-Methyltransferase Gene Polymorphisms with Korean Autism Spectrum Disorders
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Yoo HJ, Cho IH, Park M, Yang SY, Kim SA
- KMID: 1793061
- J Korean Med Sci.
- 2013 Sep;28(9):1403-1406.
- doi: 10.3346/jkms.2013.28.9.1403
This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family... -
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- Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
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Park S, Park JE, Yoo HJ, Kim JW, Cheong JH, Han DH, Kim Y, Kim BN
- KMID: 2391831
- Psychiatry Investig.
- 2015 Oct;12(4):563-565.
- doi: 10.4306/pi.2015.12.4.563
OBJECTIVE: We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. METHODS: A total of 181 subjects with ADHD... -
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- Pharmacological Treatment in Parkinson's Disease
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Lee JJ
- KMID: 2464136
- J Korean Neurol Assoc.
- 2019 Nov;37(4):335-344.
- doi: 10.17340/jkna.2019.4.1
Parkinson's disease is one of the most common neurodegenerative disorders world widely. Although curable therapies are practically not available yet, symptomatic managements using anti-Parkinson medications have shown to be quite... -
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- Difference of Val-158-Met Catechol-O-Methyltransferase Gene Polymorphism between Early- and Late-onset Obsessive-Compulsive Disorder in Korea
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Cheon KA, Kim SJ, Kim CH
- KMID: 2287240
- Korean J Psychopharmacol.
- 2006 Mar;17(2):197-202.
OBJECTIVE: Many researches strongly suggest that early- and late-onset obsessive-compulsive disorder (OCD) represent separate subtypes of the disorder, possibly with distinct underlying pathogeneses. The aim of this study was to... -
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- Catechol-O-Methyltransferase Gene Polymorphism of Attention Deficit Hyperactivity Disorder in Korean Population
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Sung YS, Lee C, Lim TS, Han SI, Lee SJ, Kim JJ
- KMID: 2340654
- J Korean Neuropsychiatr Assoc.
- 2002 Mar;41(2):215-222.
OBJECTIVE: Attention-deficit hyperactivity disorder is a highly heritable psychiatric condition of early childhood onset characterized by marked inattention, hyperactivity and impulsiveness. Genes involved in catecholamine pathways, including catechol-O-methyltransferase (COMT), represent... -
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- Placebo Effect in Clinical Trial Design for Irritable Bowel Syndrome
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Shah E, Pimentel M
- KMID: 2381168
- J Neurogastroenterol Motil.
- 2014 Apr;20(2):163-170.
Ongoing efforts to improve clinical trial design in irritable bowel syndrome have been hindered by high placebo response rates and ineffective outcome measures. We assessed established strategies to minimize placebo... -
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- The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease
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Lee HJ, Lee MS, Kim JS, Kim ER, Kang SW, Kim SK, Chung JH, Yoon KL, Han MY, Cha SH
- KMID: 2037342
- Korean J Pediatr.
- 2009 Jan;52(1):87-92.
- doi: 10.3345/kjp.2009.52.1.87
PURPOSE: Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O-methyltransfe rase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs.... -
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- Catechol-O-Methyltransferase Gene Polymorphism(Valine/Methionine) Associated Neither with Schizophrenia Nor with Bipolar Disorder in a Korean Population
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Kim MS, Chee IS, Lee SW, Shin SC, Lee YH
- KMID: 2340568
- J Korean Neuropsychiatr Assoc.
- 2001 May;40(3):510-519.
OBJECTIVE: Catechol-O-methyltransferase(COMT) is an important enzyme that inactivates biologically active or toxic catechols. Abnormal catecholamine transmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder. Polymorphism(Val/Met) of the... -
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- No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population
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Kang HJ, Choe BM, Kim SH, Son SR, Lee KM, Kim BG, Hong YS
- KMID: 2380523
- Epidemiol Health.
- 2010;32:e2010011.
OBJECTIVES: Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In... -
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- Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome?
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Deveci EO, Incebiyik , Selek S, Camuzcuoglu A, Hilali NG, Camuzcuoglu H, Erdal ME, Vural M
- KMID: 2049066
- Clin Exp Reprod Med.
- 2014 Jun;41(2):62-67.
- doi: 10.5653/cerm.2014.41.2.62
OBJECTIVE: The objective of this study was to investigate whether there was a correlation between catechol-o-methyltransferase (COMT) gene polymorphism, which is believed to play a role in the etiology of... -
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- Association Study of Val158Met Polymorphism of Catechol-O-Methyltransferase Gene and Cognitive Markers in Schizophrenia
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Park HJ, Park DY, Cho EY, Kim NR, Jeun HO, Lee YS, Lee D, Hong KS
- KMID: 2341417
- J Korean Neuropsychiatr Assoc.
- 2008 Mar;47(2):126-133.
OBJECTIVES: Catechol-O-methyltransferase (COMT) gene has been identified as a positional and functional candidate gene of schizophrenia. Although specific mechanism of increasing schizophrenia susceptibility by this gene has not been well... -
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- Association Study of Functional Catechol-O-Methyltransferase Gene Polymorphism in Korean Schizophrenia
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Park TW, Hong YJ, Park IS, Kim HS, Choi IM, Bae SY, Yoon KS, Kang DH
- KMID: 2364340
- J Korean Neuropsychiatr Assoc.
- 2001 Jul;40(4):708-717.
OBJECTIVES: Catechol-O-methyltransferase(COMT) is involved in the degradation of catecholamine neurotransmitters and has been investigated as a candidate gene in schizophrenia. Recently, possible relationship between functional COMT gene polymorphism and schizophrenia... -
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- Association between COMT and 5-HTTLPR Polymorphisms in Korean Patients with Panic Disorder : A Replication Study
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Kim SW, Choi TK, Lee SH
- KMID: 2361592
- Korean J Biol Psychiatry.
- 2016 Nov;23(4):166-172.
- doi: 10.0000/kjbp.2016.23.4.166
OBJECTIVES: We investigated whether the catechol-O-methyltransferase (COMT) and serotonin related gene polymorphisms may be associated with agoraphobia in patients with panic disorder in Korea. METHODS: The COMT gene (rs4680), 5-hydroxytryptamine (serotonin)... -
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- Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder
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Watanabe T, Ishiguro S, Aoki A, Ueda M, Hayashi Y, Akiyama K, Kato K, Shimoda K
- KMID: 2365017
- Psychiatry Investig.
- 2017 Jan;14(1):86-92.
- doi: 10.4306/pi.2017.14.1.86
OBJECTIVE: Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for... -
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- A Pilot Study for Genetic Polymorphism of Catechol-O-Methyltransferase (COMT) in Panic Disorder
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Jang YL, Yun KS, Woo JM, Lee YS, Na C, Yu BH
- KMID: 2340629
- J Korean Neuropsychiatr Assoc.
- 2001 Nov;40(6):1214-1222.
OBJECTIVES: Catecholamine metabolism has been thought to be related to the pathophysiology of panic disorder. There are two human COMT alleles, coding for a low activity enzyme, COMT L(L), and... -
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- Association Study between Obsessive-Compulsive Disorder and Val-158-Met Catechol-O-Methyltransferase Gene Polymorphism in Korea
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Cheon KA, Kim SJ, Kim CH, Koo MS, Nam YY, Park SH, Lee HS
- KMID: 2341228
- J Korean Neuropsychiatr Assoc.
- 2006 Sep;45(5):444-452.
OBJECTIVES: The definite cause of obsessive-compulsive disorder (OCD) is still unknown. Evidences from familial, twin and segregation studies support the role of a genetic factor. There are also growing evidence... -
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- Association between the Catechol-O-Methyltransferase (COMT) Val(158)Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder
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Koh MJ, Kang JI, Namkoong K, Lee SY, Kim SJ
- KMID: 2374093
- Yonsei Med J.
- 2016 May;57(3):721-727.
- doi: 10.3349/ymj.2016.57.3.721
PURPOSE: Alexithymia, defined as a deficit in the ability to recognize and describe one's own feelings, may be related to the development and maintenance of obsessive-compulsive symptoms. The aim of... -
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