Korean J Pediatr.
2009 Jan;52(1):87-92. 10.3345/kjp.2009.52.1.87.
The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease
- Affiliations
-
- 1Department of Pediatrics, Sung-Ae General Hospital, Seoul, Korea. eunicu@hotmail.com
- 2Kohwang Medical Research Institute, School of Medicine, Kyunghee University, Seoul, Korea.
- 3Department of Pediatrics, East-West Neo-medical Center, Kyunghee University, Seoul, Korea.
- 4Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea.
- KMID: 2037342
- DOI: http://doi.org/10.3345/kjp.2009.52.1.87
Abstract
- PURPOSE
Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O-methyltransfe rase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT gene polymorphisms and coronary artery abnormalities in Kawasaki disease patients.
METHODS
One hundred and one Korean children with Kawasaki disease and 306 healthy Korean control subjects were enrolled in this study. The polymorphisms of the COMT gene were analyzed by direct sequencing.
RESULTS
There were no differences in the genotype and allelic frequency of the rs4680 and rs769224 polymorphic sites between Kawasaki disease and control subjects. Further, no significant difference was found in the rs4680 polymorphism between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.32, dominant P=0.74, recessive P=0.13). However, the distribution of the rs769224 polymorphism was significantly different between patie nts with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.0077, dominant P=0.0021, recessive P=0.16).
CONCLUSION
Our results indicate that the polymorphisms of the rs769224 gene might be related to the development of coronary artery abnormalities in Kawasaki disease.
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