Psychiatry Investig.
2015 Oct;12(4):563-565. 10.4306/pi.2015.12.4.563.
Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
- Affiliations
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- 1Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
- 2Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
- 3Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea. kbn1@snu.ac.kr
- 4Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul, Republic of Korea.
- 5Department of Psychiatry, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
- KMID: 2391831
- DOI: http://doi.org/10.4306/pi.2015.12.4.563
Abstract
OBJECTIVE
We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios.
METHODS
A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios.
RESULTS
In the TDT, we found the over-transmission of the Val allele in children with ADHD (chi2=4.21, p=0.040).
CONCLUSION
These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
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