J Asthma Allergy Clin Immunol.  2002 Dec;22(4):736-741.

A case of bronchial asthma due to cefadroxil in a housewife

Affiliations
  • 1Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@madang.ajou.ac.kr

Abstract

Cephalosporins are the most important -lactams that induce IgE-mediated reactions. Also, cephalosporins have been known as a causative agent for occupational asthma in pharmaceutical workers. To our knowledge, this is the first report of cephalosporin-induced bronchial asthma in a housewife with no history of occupational exposure. We experienced a 30-year old female who had developed shortness of breath, coughing and itching sensation of the skin since 3 years ago whenever she handled drug powder for upper respiratory infections (URI) prescribed for her two sons with bronchial asthma. She had handled drug powder for 7 years because her sons had experienced frequent URI. Skin prick test with cefadroxil (10mg/ml) and cefaclor (10mg/ml) showed positive reactions. Bronchial challenge test with cefadroxil showed immediate asthmatic reaction, and bronchial challenge with cefaclor showed immediate urticaria and angioedema without significant fall in FEV1. We confirmed cefadroxil-induced bronchial asthma sensitized by intermittent inhalation in a non-occupational setting.

Keyword

asthma; skin prick test; cefadroxil; cefaclor

MeSH Terms

Adult
Angioedema
Asthma*
Asthma, Occupational
Bronchial Provocation Tests
Cefaclor
Cefadroxil*
Cephalosporins
Cough
Dyspnea
Female
Humans
Inhalation
Occupational Exposure
Pruritus
Respiratory Tract Infections
Sensation
Skin
Urticaria
Cefaclor
Cefadroxil
Cephalosporins
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