Korean J Thorac Cardiovasc Surg.
2016 Jun;49(3):145-150. 10.5090/kjtcs.2016.49.3.145.
The Effect of Pulsatile Versus Nonpulsatile Blood Flow on Viscoelasticity and Red Blood Cell Aggregation in Extracorporeal Circulation
- Affiliations
-
- 1Department of Molecular Medicine, Gachon University Graduate School of Medicine, Korea.
- 2Department of Mechatronics, Gwangju Institute of Science and Technology, Korea.
- 3Department of Anesthesiology and Pain Medicine, Korea University Medical Center, Korea.
- 4Department of Thoracic and Cardiovascular Surgery, Korea University Medical Center, Korea.
- 5Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine, Korea. dr632@gilhospital.com
- KMID: 2285801
- DOI: http://doi.org/10.5090/kjtcs.2016.49.3.145
Abstract
- BACKGROUND
Extracorporeal circulation (ECC) can induce alterations in blood viscoelasticity and cause red blood cell (RBC) aggregation. In this study, the authors evaluated the effects of pump flow pulsatility on blood viscoelasticity and RBC aggregation.
METHODS
Mongrel dogs were randomly assigned to two groups: a nonpulsatile pump group (n=6) or a pulsatile pump group (n=6). After ECC was started at a pump flow rate of 80 mL/kg/min, cardiac fibrillation was induced. Blood sampling was performed before and at 1, 2, and 3 hours after ECC commencement. To eliminate bias induced by hematocrit and plasma, all blood samples were adjusted to a hematocrit of 45% using baseline plasma. Blood viscoelasticity, plasma viscosity, hematocrit, arterial blood gas analysis, central venous O2 saturation, and lactate were measured.
RESULTS
The blood viscosity and aggregation index decreased abruptly 1 hour after ECC and then remained low during ECC in both groups, but blood elasticity did not change during ECC. Blood viscosity, blood elasticity, plasma viscosity, and the aggregation index were not significantly different in the groups at any time. Hematocrit decreased abruptly 1 hour after ECC in both groups due to dilution by the priming solution used.
CONCLUSION
After ECC, blood viscoelasticity and RBC aggregation were not different in the pulsatile and nonpulsatile groups in the adult dog model. Furthermore, pulsatile flow did not have a more harmful effect on blood viscoelasticity or RBC aggregation than nonpulsatile flow.
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