Korean J Physiol Pharmacol.  2013 Aug;17(4):339-345. 10.4196/kjpp.2013.17.4.339.

Effect of Lutein on L-NAME-Induced Hypertensive Rats

• Sung JH
• Jo YS
• Kim SJ
• Ryu JS
• Kim MC
• Ko HJ
• Sim SS

• KMID: 2285469
• DOI: http://doi.org/10.4196/kjpp.2013.17.4.339

Abstract

We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3+/-9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from 434+/-26 to 376+/-33 beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against L-NAME-induced hypertension in rats.

Keyword

Antioxidant; Hypertension; Lipid peroxidation; L-NAME; Lutein

MeSH Terms

Administration, Oral
Animals
Antioxidants
Arterial Pressure
Blood Pressure
Glutathione
Heart
Heart Rate
Hypertension
Hypertrophy
Kidney
Lipid Peroxidation
Lutein
NG-Nitroarginine Methyl Ester
Plasma
Rats
Antioxidants
Glutathione
Lutein
NG-Nitroarginine Methyl Ester