Korean J Pediatr.  2011 Jul;54(7):304-309. 10.3345/kjp.2011.54.7.304.

Usefulness of drug provocation tests in children with a history of adverse drug reaction

• Na HR
• Lee JM
• Jung JW
• Lee SY

• KMID: 2284855
• DOI: http://doi.org/10.3345/kjp.2011.54.7.304

Abstract

PURPOSE
There are very few reports of adverse drug reactions (ADR) and almost no study of drug provocation test (DPT) in Korean children. We aimed to assess the role of DPT in children with unpredictable ADRs, and compare the causative drugs and clinical characteristics between detailed history of ADRs and result of DPTs.
METHODS
We included 16 children who were experienced ADRs referred to pediatric allergy clinic at Ajou University Hospital (January 2006 to December 2009). With various suspected drugs, 71 DPTs were done in 16 patients using our own protocol, and skin tests to antibiotics were combined in ADRs to antibiotics in medical history.
RESULTS
There were 17 (23.9%) positive DPTs results out of 71 individual DPTs, and 11 patients (68.8%) from 16 patients were positive to at least one drug. Drugs causing positive reactions were acetaminophen in 5 (31%), Non-steroidal anti-inflammatory drugs in 4 (25%), penicillin in 3 (19%), cephalosporin in 2 (13%), and cotrimoxazole, macrolide and lactose in 1 each.
CONCLUSION
DPT seems a safe and useful procedure to confirm causative drug and identify safely administering alternative drugs in children with ADR.

Keyword

Adverse drug reaction; Drug provocation test; Child

MeSH Terms

Acetaminophen
Anti-Bacterial Agents
Child
Drug Toxicity
Humans
Hypersensitivity
Lactose
Penicillins
Skin Tests
Thiones
Trimethoprim, Sulfamethoxazole Drug Combination
Acetaminophen
Anti-Bacterial Agents
Lactose
Penicillins
Thiones