Korean J Phys Anthropol.
1998 Dec;11(2):361-375.
Age - related Changes of T cells,B cells Distribution in C57BL/6 Mice Thymus,Spleen and Popliteal Lymph Node
- Affiliations
-
- 1Department of Anatomy, College of Medicine, Kyunghee University, Korea.
- 2Department of Pathology, National Institute of Toxicological Research, Korea.
Abstract
- The following experiment was performed to clarify distributional changes of the Ly1, L3T4, Ly2 positive T cells and IgM positive B cells 1, 4, 8, 12 and 40 weeks after birth. Thymus, spleen and lymph node were removed and immunohistochemical staining such as avidin -biotin -peroxidase complex method was used. The results obtained from above epxperiment were as follows; 1. Ly1 positive T cells were decreased after 8 weeks in the thymus and spleen. these were decreased after 40 weeks in the lymph node. 2. There was no difference L3T4 positive T cells in the thymus, but in the spleen decrease of cell number was shown after 40 weeks. 3. Ly2 postive T cells were decreased after 4 weeks in the thymus, after 40 weeks in the spleen. There was no change of distribution in the lymph node. 4. There was no difference distribution of IgM positive B cells. The results suggest that the age related decrease of the immunity is caused by decrease of cellular immunity related to T cell depletion.
Keyword
- Thymus; Spleen; Lymph Node; Mouse; Age
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Age-related Changes of Mac1-positive Cell Distribution in the Thymus, Spleen and Popliteal Lymph Node in C57BL/6 Mice
- Distribution of anti-TNP forming cells after TNP-LPS injection in mice popliteal lymph node and spleen
- Effect of polyadenylic.polyuridylic acid on the proliferative responsiveness of mouse thymus and spleen cells
- Generation and Characterization of Alloenic Radiation Bone Marrow Chimera
- Immunohistochemical Characterization of Dendritic Cells after Systemic Administration of Staphylococcal Enterotoxin B
