Endocrinol Metab.  2015 Jun;30(2):124-141. 10.3803/EnM.2015.30.2.124.

Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders

• Clarke H
• Dhillo WS
• Jayasena C

• KMID: 2282002
• DOI: http://doi.org/10.3803/EnM.2015.30.2.124

Abstract

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling causes hypogonadotrophic hypogonadism in humans and other mammals. Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation. In addition, a growing body of evidence suggests that kisspeptin signaling be regulated by nutritional status and stress. Kisspeptin may also represent a novel potential therapeutic target in the treatment of fertility disorders. Early human studies suggest that peripheral exogenous kisspeptin administration stimulates gonadotrophin release in healthy adults and in patients with certain forms of infertility. This review aims to concisely summarize what is known about kisspeptin as a regulator of reproductive function, and provide an update on recent advances within this field.

Keyword

Kisspeptins; Fertility; Hypothalamus; Gonadotropin-releasing hormone; Gonadotrophins

MeSH Terms

Adult
Dynorphins
Fertility
Gonadotropin-Releasing Hormone
Humans
Hypogonadism
Hypothalamus
Infertility
Kisspeptins
Mammals
Neurokinin B
Neuropeptides
Nutritional Status
Axis, Cervical Vertebra
Dynorphins
Gonadotropin-Releasing Hormone
Kisspeptins
Neurokinin B
Neuropeptides

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