- Kisspeptin/G protein-coupled receptor-54 system as an essential gatekeeper of pubertal development
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Rhie YJ
- KMID: 2047461
- Ann Pediatr Endocrinol Metab.
- 2013 Jun;18(2):55-59.
- doi: 10.6065/apem.2013.18.2.55
Puberty is the end-point of a complex series of developmental events, defined by the dynamic interaction between genetic factors and environmental cues, ultimately leading to the attainment of reproductive capacity.... -
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- An update on the genetic causes of central precocious puberty
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Shin YL
- KMID: 2328143
- Ann Pediatr Endocrinol Metab.
- 2016 Jun;21(2):66-69.
- doi: 10.6065/apem.2016.21.2.66
Central precocious puberty (CPP) is caused by the premature reactivation of the hypothalamic-pituitary-gonadal axis. Genetic, nutritional, and environmental factors play a crucial role in determining pubertal timing. Recently mutations in... -
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- Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
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Clarke H, Dhillo WS, Jayasena C
- KMID: 2282002
- Endocrinol Metab.
- 2015 Jun;30(2):124-141.
- doi: 10.3803/EnM.2015.30.2.124
Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone... -
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- KISS1 Gene Polymorphisms in Korean Girls with Central Precocious Puberty
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Rhie YJ, Lee KH, Ko JM, Lee WJ, Kim JH, Kim HS
- KMID: 2129608
- J Korean Med Sci.
- 2014 Aug;29(8):1120-1125.
- doi: 10.3346/jkms.2014.29.8.1120
Kisspeptin/G-protein couple receptor-54 (GPR54) system plays a key role in the activation of the gonadotropic axis at puberty. Central precocious puberty (CPP) is caused by the premature activation of hypothalamic... -
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- A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats
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Karamikheirabad M, Behzadi G, Faghihi M, Raoofian R, Ejtemaei Mehr S, Zuure WA, Sadeghipour HR
- KMID: 2167493
- Clin Exp Reprod Med.
- 2013 Dec;40(4):155-162.
- doi: 10.5653/cerm.2013.40.4.155
OBJECTIVE: Stress is known to be an inhibitor of the reproductive hypothalamic-pituitary-gonadal (HPG) axis. However, the neural and molecular connections between stress and reproduction are not yet understood. It is... -
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