Korean J Pediatr.  2010 Feb;53(2):215-221. 10.3345/kjp.2010.53.2.215.

Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy

• Baek SA
• Hahn WH
• Cho BS
• Kim SD

• KMID: 2281369
• DOI: http://doi.org/10.3345/kjp.2010.53.2.215

Abstract

PURPOSE
Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN). Our aim was to investigate the association between single-nucleotide polymorphisms (SNPs) in IL-17 receptor A (IL-17RA) gene and childhood IgAN.
METHODS
We analyzed the SNPs in the IL-17RA in 156 children with biopsy-proven IgAN and 245 healthy controls. We divided the IgAN patients into 2 groups and compared them with respect to proteinuria (< or =4 and >4 mg/m2/h, < or =40 and >40 mg/m2/h, respectively) and the presence of pathological levels of biomarkers of diseases such as interstitial fibrosis, tubular atrophy, or global sclerosis.
RESULTS
No difference was observed between the SNP genotypes rs2895332, rs1468488, and rs4819553 between IgAN patients and control subjects. In addition, no significant difference was observed between allele frequency of SNPs rs2895 332, rs1468488, and rs4819553 between patients in the early and advanced stage of the disease. However, significant difference was observed between the genotype of SNP rs2895332 between patients with proteinuria (>4 mg/m2/h) and those without proteinuria (codominant model OR 0.36, 95% CI 0.19-0.66, P<0.001; dominant model OR 0.35, 95% CI 0.17-0.69 P=0.002; recessive model OR 0.12, 95% CI 0.01-1.06 P=0.025).
CONCLUSION
Our results indicate that the SNP in IL-17RA (rs2895332) may be related to the development of proteinuria in IgAN patients.

Keyword

Glomerulonephritis; IGA; Receptor; Interleukin-17; Children; Polymorphism

MeSH Terms

Atrophy
Biomarkers
Child
Fibrosis
Gene Frequency
Genotype
Glomerulonephritis
Glomerulonephritis, IGA
Humans
Immunoglobulin A
Interleukin-17
Polymorphism, Single Nucleotide
Proteinuria
Receptors, Interleukin-17
Immunoglobulin A
Interleukin-17
Receptors, Interleukin-17