Korean J Nephrol.  1999 May;18(3):390-399.

Gene Ploymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase in Patients with IgA Nephropathy

• Kim IH
• Kim W
• Kang SK
• Lee DY
• Koh GY
• Lee KY
• Park SB
• Kim HC
• Park SK

Abstract

To evaluate the association between ACE gene I/D polymorphism and ecNOS gene a/b polymorphism in IgA nephropathy, 158 IgA nephropathy patients and 121 control subjects were examined. In genotype distribution of the ACE gene I/D polymorphism, there was no significant difference in genotype distribution between controls and IgA nephropathy patients. We also examined the association between ACE genotype and clinical characteristics in the patients with IgA nephropathy. The incidence of hypertension in patients with DD genotype was higher than that of other genotypes. There were no significant association between I/D polymorphism distribution and chronic renal failure, nephrotic range proteinuria, and glomerular sclerosis in IgA nephropathy. In genotype distribution of ecNOS gene a/b polymorphism, there was no significant difference between IgA nephropathy patients and controls. There was no significant difference in frequency of chronic renal failure, hypertension, nephrotic range proteinuria and glomerular sclerosis among ecNOS genotypes. In addition, we failed to detect any significant association between the ACE and ecNOS gene-polymorphis ms and the decline of renal function in IgA nephropathy. A further study with larger number of patient population would be necessary.

Keyword

IgA Nephropathy; Angiotensin Converting Enzyme Gene; Endothelial Nitric Oxide Gene; Ploymorphism

MeSH Terms

Angiotensins*
Genotype
Glomerulonephritis, IGA*
Humans
Hypertension
Immunoglobulin A*
Incidence
Kidney Failure, Chronic
Nitric Oxide Synthase Type III*
Peptidyl-Dipeptidase A*
Proteinuria
Sclerosis
Angiotensins
Immunoglobulin A
Nitric Oxide Synthase Type III
Peptidyl-Dipeptidase A