Korean J Pediatr.  2008 Nov;51(11):1205-1210. 10.3345/kjp.2008.51.11.1205.

The significance of corpus callosal size in the estimation of neurologically abnormal infants

Affiliations
  • 1Department of Pediatrics, Wonkwang University College of Medicine , Iksan, Korea. chan33@wonkwang.ac.kr

Abstract

PURPOSE: The development of the corpus callosum occupies the entire period of cerebral formation. The myelination pattern on magnetic resonance imaging (MRI) is very useful to evaluate neurologic development and to predict neurologic outcome in high risk infants. The thickness of the corpus callosum is believed to depend on the myelination process. It is possible to calculate the length and thickness of the corpus callosum on MRI. Thus, we can quantitatively evaluate the development of the corpus callosum. We investigated the clinical significance of measuring various portions of the corpus callosum in neonate with neurologic disorders such as hypoxic brain damage and seizure disorder.
METHODS
Forty-two neonates were evaluated by brain MRI. We measured the size of the genu, body, transitional zone, splenium, and length of the corpus callosum. Each measurement was divided by the total length of the corpus callosum to obtain its corrected size. The ratio of corpus callosal length and the anteroposterior diameter of the brain was also measured.
RESULTS
There was no statistical significance in the sample size of each part of the corpus callosum. However, the corrected size or the ratio of body of the corpus callosum correlated with periventricular leukomalacia and hypoxic ischemic encephalopathy.
CONCLUSION
There was no statistical significance in the sample size of each part of the corpus callosum. However, the corrected size or the ratio of body of the corpus callosum correlated with periventricular leukomalacia and hypoxic ischemic encephalopathy.

Keyword

Corpus callosum; Hypoxia-ischemia; Brain; Leukomalacia; Periventricular

MeSH Terms

Brain
Corpus Callosum
Epilepsy
Humans
Hypoxia, Brain
Hypoxia-Ischemia, Brain
Infant
Infant, Newborn
Leukomalacia, Periventricular
Magnetic Resonance Imaging
Myelin Sheath
Nervous System Diseases
Sample Size
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