J Korean Soc Radiol.  2020 Sep;81(5):1184-1193. 10.3348/jksr.2019.0113.

Microbleeds in the Corpus Callosum in Anoxic Brain Injury

• Kim CS
• Park DW
• Kim TY
• Lee YJ
• Lee JY

• KMID: 2507441
• DOI: http://doi.org/10.3348/jksr.2019.0113

Abstract

Purpose
This study was performed to evaluate the relationship between callosal microbleeds and anoxic brain injury.
Materials and Methods
Twenty-seven patients with anoxic brain injuries were analyzed and retrospectively compared to the control group of patients without a history of anoxic brain injury using Fisher's exact test regarding comorbidities and cerebral microbleeds. The patient group was subdivided according to the presence of callosal microbleeds. Fisher's exact test was used to compare the presence of typical MRI findings of anoxic brain injury, use of cardiopulmonary resuscitation, and prognosis. The Mann-Whitney U test was used to compare the interval between the occurrence of anoxic brain injury to MRI acquisition.
Results
The prevalence of cerebral microbleeds in the patient group was 29.6%, which was significantly higher than that in the control group at 3.7% (p = 0.012). All cerebral microbleeds in the patient group were in the corpus callosum. Compared with the callosal microbleed-absent group, the callosal microbleed-present group showed a tendency of good prognosis (6/8 vs. 11/19), fewer typical MRI findings of anoxic brain injury (2/8 vs. 10/19), and more cardiopulmonary resuscitation (6/8 vs. 12/19), although these differences did not reach statistical significance (p = 0.35, p = 0.19, and p = 0.45, respectively).
Conclusion
Callosal microbleeds may be an adjunctive MRI marker for anoxic brain injury.

Keyword

Anoxic Brain Damage; Brain Hemorrhage; Corpus Callosum