Korean J Pediatr.  2004 Dec;47(12):1356-1359.

A Case of Aplastic Anemia following Hepatic Failure by Acute Hepatitis

• Ku HJ
• Lim YT
• Park JH

Abstract

Aplastic anemia following acute hepatitis or acute hepatic failure is an uncommon disease and has a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 10- year-old girl. She was admitted because of jaundice and lethargy for 8 days. Laboratory findings revealed marked elevated serum transaminases and bilirubin levels, prolonged prothrombin time and partial thromboplastin time, and massive hepatic necrosis on the pathological study. There was no evidence of metabolic, toxic or autoimmune hepatitis. During the treatment of acute hepatic failure, pancytopenia developed and marked hypocellularity of all hematopoietic elements in bone marrow was revealed. She recovered partially from aplastic anemia after treatment with anti-thymocyte globulin, corticosteroid and cyclosporine.

Keyword

Acute hepatitis; Acute hepatic failure; Aplastic anemia

MeSH Terms

Anemia, Aplastic*
Antilymphocyte Serum
Bilirubin
Bone Marrow
Cyclosporine
Female
Hepatitis*
Hepatitis, Autoimmune
Humans
Jaundice
Lethargy
Liver Failure*
Liver Failure, Acute
Massive Hepatic Necrosis
Pancytopenia
Partial Thromboplastin Time
Prognosis
Prothrombin Time
Transaminases
Antilymphocyte Serum
Bilirubin
Cyclosporine
Transaminases