Korean J Pediatr.  2004 Dec;47(12):1293-1299.

Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant

• Kim KD
• Son BH
• Oh CW
• Lee JA
• Kim SW

Abstract

PURPOSE
This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants.
METHODS
Interleukin-1beta(IL-1beta), Interleukin-6(IL-6), Tumor necrosis factor-alpha(TNF-alpha) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records.
RESULTS
Cord blood levels of IL-1beta, IL-6 and TNF-alpha in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group.
CONCLUSION
Cord blood levels of IL-1beta, IL-6 and TNF-alpha in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF-alpha & IL-1beta in this study.

Keyword

Cytokine; Interlukin(IL-1beta, IL-6, TNF-alpha); Cerebral palsy; Premature

MeSH Terms

Asphyxia
Cerebral Palsy*
Cytokines*
Enzyme-Linked Immunosorbent Assay
Fetal Blood*
Humans
Infant, Newborn
Infant, Premature*
Interleukin-6
Medical Records
Necrosis
Paralysis
Plasma
Pneumonia
Retrospective Studies
Sepsis
Tumor Necrosis Factor-alpha
Cytokines
Interleukin-6
Tumor Necrosis Factor-alpha