Korean J Pediatr Infect Dis.  2009 Jun;16(1):6-12.

New Antimicrobial Agents for Children

• Eun BW

Abstract

There are relatively few novel antimicrobial agents despite the dramatic increase in antimicrobial resistance and multiple drug resistance of clinical isolates worldwide. Vancomycin is still the most widely used antibiotic for treating resistant Gram-positive coccal infections in children, especially for methicillin-resistant Staphylococcus aureus. For children with Gram-positive coccal infections where vancomycin is not effective or older therapeutic agents cannot be tolerated, linezolid, quinupristin-dalfopristin or daptomycin may be useful in the appropriate clinical setting. For Gram-negative infections, new carbapenems await clinical application. Tebipenem pivoxil is a novel oral carbapenem undergoing clinical trials for acute otitis media in pediatric patients. Antiviral drug development is now progressing at the pace of antibiotic development 30 years ago. Newer antiviral agents used for the treatment of herpes viruses and hepatitis C virus infections in children are included in this review.

Keyword

Anti-Bacterial Agents; Antiviral Agents; Child

MeSH Terms

Acetamides
Anti-Bacterial Agents
Anti-Infective Agents
Antiviral Agents
Carbapenems
Child
Daptomycin
Drug Resistance, Multiple
Hepacivirus
Humans
Methicillin-Resistant Staphylococcus aureus
Otitis Media
Oxazolidinones
Vancomycin
Virginiamycin
Linezolid
Acetamides
Anti-Bacterial Agents
Anti-Infective Agents
Antiviral Agents
Carbapenems
Daptomycin
Oxazolidinones
Vancomycin
Virginiamycin