Korean J Pediatr.  2006 Mar;49(3):242-250. 10.3345/kjp.2006.49.3.242.

Present status and prospects of Haemophilus influenzae type b(Hib) immunization

Affiliations
  • 1Department of Pediatrics, College of Medicine, Ewha Woman's University, Seoul, Korea kaykim@ewha.ac.kr

Abstract

Haemophilus influenzae type b(Hib) conjugate vaccines prevent Hib disease in individuals and reduce the carriage and transmission of the organism in the community. The incidence of Hib disease has been decreased dramatically in a diverse range of countries through the use of a variety of conjugate vaccines and vaccine schedules. In some countries, the vaccine has caused a near-disappearance of invasive Hib disease through a combination of direct protection and herd immunity. The effectiveness of the vaccine was not modified by the type of conjugate vaccine, the number of doses given(two, three or four), age at first vaccination(two months, 42 to 90 days, three months) and whether the vaccine was tested in an industrialized or developing country. Over 15 years of international experience with vaccines has also demonstrated that they are safe. In 2004, Hib vaccines were adapted in routine immunization in 92 countries in the world. Decisions regarding the use of the Hib vaccine in routine immunization schedules depend not only on the effectiveness and efficacy of the vaccine but also on factors such as burden of disease, vaccine cost, and competing priorities. In Korea, Hib disease burden seemed to be lower than other developed countries(~10/100,000). Moreover Hib vaccines showed excellent immunogenicity in Korean children in many studies. Therefore, a potential approach to economize the cost of Hib vaccines could be to explore the possibilities of using reduced vaccine doses for immunization as some other countries.

Keyword

Haemophilus influenzae type b; Immunization

MeSH Terms

Appointments and Schedules
Child
Developing Countries
Haemophilus influenzae type b
Haemophilus influenzae*
Haemophilus*
Humans
Immunity, Herd
Immunization Schedule
Immunization*
Incidence
Korea
Vaccines
Vaccines, Conjugate
Vaccines
Vaccines, Conjugate
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