Korean J Pediatr Hematol Oncol.  2003 Oct;10(2):287-292.

Three Cases of Childhood Renal Cell Carcinoma Including 2 Cases with Systemic Immunotherapy

• Chung HR
• Park ES
• Choi HS
• Shin HY
• Ahn HS

Abstract

Renal cell carcinoma (RCC) is a malignancy arising from the tubular epithelial cell. RCC is a rare disease in children with an incidence of 0.1~0.3% of all childhood cancer. It is known that RCC in children is different from its adult counterpart in some aspects. Although conventional treatment of RCC is radical nephrectomy with lymph node dissection, we tried systemic treatment for advanced disease. Because metastasis is common at diagnosis and RCC is usually resistant to radiotherapy or chemotherapy, immunotherapy such as interferon-alpha (IFN-alpha) or interleukin-2 (IL-2) is investigated and clinically used. We have experienced 3 children with RCC and two with stage IV disease were treated with systemic immunotherapy. One who had stage IV, recurred RCC is followed-up for 16 months without the evidence of disease progression with IFN-alpha and IL-2. We report these 3 cases with a brief review of literatures.

Keyword

Renal cell carcinoma; Immumotherapy; Childhood

MeSH Terms

Adult
Carcinoma, Renal Cell*
Child
Diagnosis
Disease Progression
Drug Therapy
Epithelial Cells
Humans
Immunotherapy*
Incidence
Interferon-alpha
Interleukin-2
Lymph Node Excision
Neoplasm Metastasis
Nephrectomy
Radiotherapy
Rare Diseases
Interferon-alpha
Interleukin-2